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Free Light Chains: Is the “Gold Standard” Still Really a Standard?

Published: 7/27/2026 | Modified: 7/27/2026

Abstract

In this 60-minute webinar, Pr. Oliver Frey will notably:

  • Introduce plasma cell neoplasms and other diseases with paraprotein
  • Explain the role of free light chains (FLC) in diagnosis and follow-up of plasma cell neoplasms
  • Give an overview on available free light chain assays: technical and methodological aspects
  • Outline what is important in selecting a FLC assay: reference interval, CKD, clinical performance
  • Detail lessons learned when switching FLC assays

What will you learn?

  • Understand the role of free light chains in plasma cell disorders

    Learn how FLC testing supports the diagnosis, prognosis, and monitoring of multiple myeloma and other paraprotein-related diseases.

  • Evaluate and select the most appropriate FLC assay

    Explore the technical and methodological differences between available assays, including the impact of reference intervals and chronic kidney disease (CKD) on result interpretation.

  • Apply best practices when transitioning between FLC platforms

    Gain practical insights into assay switching, clinical performance considerations, and strategies to ensure consistent patient monitoring and accurate clinical decision-making.

The free light chains are now a biomarker of malignancy
Pr. Oliver Frey

About Pr. Oliver Frey

Pr. Oliver Frey is a specialist in laboratory medicine.

He is medical director of the IMD Berlin MVZ and specializes in immunological diagnostics and the diagnosis of hematological neoplasia.

Pr. Frey is also involved in accreditation procedures as an expert assessor in the field of immunology and is committed to quality-assured, precise and patient-centered medical diagnostics.

Pr. Oliver Frey

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