The high-resolution method for hemoglobin disorders screening.
Hemoglobin electrophoresis is a well-established technique routinely used in clinical laboratories to screen patient samples for hemoglobinopathies (hemoglobin variants and thalassemias).
Many international organizations, including the Thalassaemia International Federation (TIF), the Centers for Disease Control and Prevention (CDC), and the Association of Public Health Laboratories (APHL), recognize the benefits of Sebia Capillary Electrophoresis (CE) technology, particularly its high resolution and the clarity of hemoglobin fraction profiles for screening hemoglobin disorders.
The CAPI 3 HEMOGLOBIN(E) and the MINICAP HEMOGLOBIN(E) kits are intended for the separation of the normal hemoglobins (A, A2 and F) in human blood samples, and for the detection of the major hemoglobin variants (S, C, E and D), by Capillary Electrophoresis in alkaline buffer (pH 9.4) with the Sebia CAPILLARYS 3 and MINICAP FLEX-PIERCING instruments.
The CAPILLARYS 3 and MINICAP FLEX-PIERCING instruments are automated analyzers which perform a complete hemoglobin profile for the quantitative analysis of the normal hemoglobin fractions A, A2 and F and for the detection of major hemoglobin variants S, C, E and D. The assay is performed on the hemolysate of whole blood samples collected in tubes containing KEDTA as anticoagulant.
CAPILLARYS instruments perform all sequences automatically, from primary tube sampling to final clear-cut profile, enabling precise quantification and presumptive identification of the most common hemoglobins. Load-and-go workflow improves efficiency and reduces hands-on time.
Whole-blood, capped tubes with automated on-board mixing removes the need for manual sample processing.
CAPILLARYS instruments deliver high‑resolution separation of most hemoglobin variants—including the common ones (Hb S, Hb C, Hb D, and Hb E) along with precise quantification of Hb A2 and Hb F for reliable thalassemia screening. In addition, the Sebia Capillary Electrophoresis technique is highly reproducible, and the migration positions generated by the software can assist in the identification of rare hemoglobin variants.
Capillary Electrophoresis enables clean separation of Hb E from Hb A2 and simplifies the detection of Hb Bart’s and Hb H associated with alpha-thalassemia syndromes. The built-in Hb variant library, together with X-axis migration positions, supports the presumptive identification of rare hemoglobin variants.
With a wide range of capillary instruments available, the Sebia hemoglobin testing method can meet the diverse needs and variable workloads of laboratories involved in screening for hemoglobin disorders.
Whole blood samples are used and are analysed directly on Capillary instruments.
Throughput (tests/hour)*
HEMOGLOBIN(E)
*Firmware-dependent; contact your local Sebia representative for current information.
**Maximum Capacity or MC designation refers to Tube Loader CAPILLARYS 3 - P/N: 1249 and Rack Conveyor CAPILLARYS 3 - P/N: 1250 associated with CAPILLARYS 3 TERA - P/N: 1246.
Each Sebia Capillary instrument has a dedicated reagent kit to perform Hemoglobin fractions analysis.
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Please contact your local Sebia representative. Information intended for healthcare professionals.
Carefully read the instructions in the reagent package inserts and instrument manuals.